Cortisol, 21-(hydrogen succinate) (8CI)

Name	hydrocortisone 21-hemisuccinate*free acid
Synonyms	NSC 7576 Hydrocortisone Succinate Hydrocortisone Hemisuccinate Hydrocortisone 21-hemisuccinate Cortisol, hydrogen succinate (7CI) HYDROCORTISONEHEMISUCCINATE(ANHYDROUS) hydrocortisone 21-(hydrogen succinate) Cortisol, 21-(hydrogen succinate) (8CI) hydrocortisone 21-hemisuccinate*free acid 11b,17a,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 4-{[(11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid 4-{[(8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoic acid 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
CAS	2203-97-6
EINECS	218-612-3
InChI	InChI=1/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22?,23-,24-,25-/m0/s1

Molecular Formula	C25H34O8
Molar Mass	462.53
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	170～172℃
Boling Point	685.5±55.0 °C(Predicted)
Specific Rotation(α)	[α]D20 +147～+153° (c=1, C2H5OH) (After Drying)
Solubility	Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.
Appearance	neat
Color	White to Off-White
pKa	pKa 5.10/5.64(20% aq EtOH/50% aq EtOH) (Uncertain)
Storage Condition	−20°C
Refractive Index	1.587
In vitro study	Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC 50 s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	TU5010147

Use	Hydrocortisone succinate is a corticosteroid used as an analytical and chromatographic reagent. Used as a pharmaceutical intermediate
biological activity	Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID). Hydrocortisone hemisuccinate inhibit the biological activity of IL-6 and IL-3, IC50 values are 6.7 and 21.4 μM respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC).
Animal Model:	Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis
Dosage:	30 mg/kg
Administration:	P.o. twice daily for 5 days
Result:	Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.

Last Update：2024-04-10 22:29:15

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